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publicationDate 1996-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0519720-B1
titleOfInvention Immunoassay of human granulocyte elastase
abstract The total quantity of elastase in a specimen containg human granulocyte elastase in the form of a mixture of free elastase with an elastase-inhibitor complex or complexes is precisely detected by adding an inhibitor to convert the free elastase into an elastase-inhibitor complex. The elastase present can then be measured by immunoassay as the total amount including the previously-existing elastase-inhibitor complex. It is thus possible to measure precisely the total amount of elastase in mucus collected from the cervical canal of a pregnant woman, sputum or a rinsed solution of bronchovesicular lavage in which free elastase is mixed with an elastase-inhibitor complex. It is also possible to predict and prevent threatened premature delivery, premature delivery or premature rupture of membranes by immunoassay of mucus collected from the cervical canal of a pregnant woman; to make a diagnosis of chronic or repetitive airway infections and pulmonary emphysema based on chronic respiratory diseases by immunoassay of sputum and a rinsed solution of bronchovesicular lavage; and to make a diagnosis of urinary tract infections by immunoassay of urine.
priorityDate 1991-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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