| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ee5dece8cd6ccb38a0350b77a83e5e98 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-367 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-493
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-487
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-734
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-367
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-24 |
| filingDate |
1992-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f12f11236a6e542f49588d47053f2143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f707ec9bbe9f396cc486b1f99383465d |
| publicationDate |
1992-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0518110-A2 |
| titleOfInvention |
Process for the preparation of pure enatiomers of 4-[4-(4'-tert.butylphenyl)-2-hydroxybutoxy]-benzoic acid and its alkyl ester |
| abstract |
The pure enantiomers of 4- [4- (4'-tert-butylphenyl) -2-hydroxybutoxy] benzoic acid and their alkyl esters can be prepared in surprisingly good yield by reacting the pure enantiomeric forms of S (-) - or R ( +) - 4- (4'-tert-Butylphenyl) -1,2-epoxybutane with 4-hydroxybenzoic acid alkyl ester at elevated temperature in DMF and in the presence of 4-hydroxybenzoic acid alkyl ester sodium salt. The raw reaction product is then to be separated off. Either the stereochemically pure LIFIBROL ester is obtained by recrystallization or the precipitated LIFIBROL enantiomer is prepared in pure, crystalline form by mild alkaline saponification and subsequent acidification. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0622351-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1045083-C
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-667260-B2 |
| priorityDate |
1991-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |