http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0516180-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2de3beee83d9c19278da409b72c777a8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-42 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-0091 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 |
| filingDate | 1988-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa59a018d537ad05881e988a1adb9b69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_156db00e2d809bd00983d9dfed3f70f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e742bb56c64d8000c212c01aba313760 |
| publicationDate | 1992-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0516180-A1 |
| titleOfInvention | Novel sulfonamide derivatives |
| abstract | A sulfonamide derivative of the general formula:n n wherein, n R¹ represents nn (i) COOR¹¹, (ii) CH₂OR¹² or (iii) CONR¹³R¹⁴, wherein nR¹¹ represents a hydrogen atom, alkyl group of from 1 to 20 carbon atom(s), carbocyclic ring unsubstituted or substituted by an alkyl or alkoxy group of from 1 to 4 carbon atom(s) or halogen atom, or steroid, nR¹² represents a hydrogen atom or COR¹⁵, nR¹³ and R¹⁴ each represent a hydrogen atom or alkyl group of form 1 to 4 carbon atom(s) or nNR¹³R¹⁴ represents an amino acid residue or heterocyclic ring, or nR¹⁵ represents an alkyl group of from 1 to 4 carbon atom(s) or phenyl group, n n n X b representsn (i) bond, (ii) alkylene group of from 1 to 4 carbon atoms or (iii) alkenylene group of from 2 to 4 carbon atoms (with the proviso that CH=CHCH₂ and CH₂CH=CHCH₂ are excluded), R 2b representsn (i) hydrogen atom, (ii) halogen atom or (iii) alkyl group of from 1 to 4 carbon atom(s), the configuration of a double bond between C₅ and C₆ in the general formula (B) is cis, ncyclodextrin clathrates thereof, or non-toxic salts thereof in case that R¹¹ represents a hydrogen atom or NR¹³R¹⁴ represents an amino acid residue, possess an antagonistic activity on TXA₂, in particular, inhibit blood platelet aggregation and contraction of artery, and are, therefore, useful for prevention and/or treatment of inflammation, hypertension, thrombus, cerebral apoplexy, asthma, cardiac infarction, angina pectoris, cerebral infarction and death by aucte cardiac diseases in mammales, in particular in humans, which are induced by thromboxane A₂. |
| priorityDate | 1988-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 397.