| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c999fee6428152a996011d506925c2d7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0613 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-14 |
| filingDate |
1992-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95ef577f8ec05cb89069ddcf43ba7350
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2552746790e861becbd62a98c1530159
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_464efd221d2370bb68742add2a9bc6f6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc1c27b02f1538c1ab1cfe65d77ef680 |
| publicationDate |
1992-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0514936-A1 |
| titleOfInvention |
Method of preparing alpha-L-aspartyl-L-phenylalanine methyl ester |
| abstract |
Industrial scale neutralization and crystallization of α -APM from an acid addition salt of α -APM is effected efficiently, and the solid-liquid separatabillty of the α -APM slurry is improved to elevate the yield of crystals of α -APM to be obtained. n In neutralizing an acid addition salt of α -APM with an aqueous medium, the α -APM concentration in the neutralized liquid is defined to fall within the range of from 3 to 10 % at the end of the neutralization. Then, the liquid is heated up to 50 to 80 ° C and neutralization is effected with stirring to the isoelectric point of α -APM; or after the neutralization, the neutralized liquid is heated. The neutralized liquid is thereafter cooled with or without stirring so that crystals of α -APM are precipitated out. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0654480-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5728863-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9524420-A1 |
| priorityDate |
1991-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |