| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-01 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-10 |
| filingDate |
1992-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_347900d4825a988535d61c53acc730b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1318114dc9c07cb3052ab1d8cfbb6f32 |
| publicationDate |
1992-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0514090-A1 |
| titleOfInvention |
Procedure for the inversion of the stereochemistry at C13 of avermectin aglycone compounds |
| abstract |
The natural stereochemistry at the 13-position of avermectin aglycones, normally alpha -oriented or below the plane of the molecule, is inverted or epimerized into the beta -position. The procedure starts with the avermectin aglycone compounds where the 13 alpha -hydroxy group is substituted with a leaving group. Treatment of the substituted compound with tetra alkyl ammonium nitrate displaces the leaving group, substitutes a nitrate ester or a nitrooxy group, for the hydroxy and inverts the 13-stereochemistry to beta . Reduction of the nitrooxy group returns the 13-hydroxy group and retains the 13- beta configuration. The intermediate 13-nitrooxy compounds are themselves potent anti-parasitic agents. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004058771-A1 |
| priorityDate |
1991-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |