| abstract |
The process described, which is used for the preparation of 2'-deoxynucleosides and 2 ', 3'-dideoxy-2', 3'-didehydronucleosides, consists in reacting a nucleoside comprising hydroxyl groups in the 2 'and 3 positions with a mixture of bromide or acyl chloride and HX, X representing Br or Cl, at a moderate temperature, in order to produce a haloacyl nucleoside derivative which can be deprotected and reduced to form the desired compound. |