| abstract |
Compounds of the formula <CHEM> wherein R<1> represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralkanoyl, heterocyclylcarbonyl or a group of the formula <CHEM> R<2> represents alkyl, cycloalkylalkyl or aralkyl; R<3> represents hydrogen and R<4> represents hydroxy or R<3> and R<4> together represent oxo; R<5> represents alkoxycarbonyl or alkylcarbamoyl; R<6> and R<7> together represent trimethylene or tetramethylene optionally substituted by alkyl or on adjacent carbon atoms by tetramethylene; R<8> represents alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aroyl, aralkanoyl or heterocyclylcarbonyl; and R<9> represents alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, cyanoalkyl, carbamoylalkyl, alkylthioalkyl, alkoxyalkyl or alkoxycarbonylalkyl, and pharmaceutically acceptable acid addition salts of those compounds of formula I which are basic, inhibit aspartyl proteases of viral origin and can be used in the form of medicaments for the prophylaxis or treatment of viral infections. They can be manufactured according to generally known methods. |