| abstract |
Viral inhibition, in particular inhibition of HIV using DNA sequences comprising multiple target response elements. For the first time, a structure, proposed for use in genetic therapy, is subject to biological regulation. The protective gene product is only expressed if the cell becomes infected and a viral protein is made. The DNA structure of the invention comprises a vector and a promoter operably linked to at least one target response element, so that the elements are transcribed in tandem. The DNA structure can be used in the treatment of viral infections, including HIV-associated diseases, by obtaining cells from an HIV patient, by transforming cells using the structure, and by administration of the transformed cell to the patient. |