| abstract |
The invention relates to new substituted anthraquinones of the formula (alpha) in which R1 and R2 independently represent H, C1-C10 alkyl, aryl, arylalkyl, alkylaryl, or R1 and R2 with the adjacent N nitrogen atom form a ring. substituted or unsubstituted cyclic which may contain additional heteroatoms, n and m independently represent 1, 2 or 3; Represented halogen, OH, alkoxy, OCO (NR3R4), S-C (NH2) = NR5, or when m = 1, it comprises an oxyrane ring with the adjacent oxygen atom; R3, R4 and R5 independently represent H, alkyl or aryl; X represents H, OH, NR6R7, Cl, Br, I, F, alkyl, aryl, alkoxy, aryloxy, COOR8 or CONR9R10; and R6, R7, R8, R9 and R10 independently represent H, lower alkyl or aryl used in the inhibition of protein kinase C as well as in the treatment of conditions associated with or affected by the inhibition of protein kinase C, including cancerous tumors, inflammatory diseases, reperfusion injuries as well as cardiac dysfunctions related to reperfusion injuries. |