| abstract |
The present invention concerns aminoacyl and oligopeptidyl derivatives of allopurinol (1,5-dihydro-4H-pyrazolo-[3,4-d]-pyrimidin-4-one) of general formula (I), and related salts withn npharmacologically-acceptable cations, in which n is an integer between 2 and 6, preferably 5, Y is H or CO-A, in which A is a racemic or chiral amino acid, dipeptide, tripeptide, tetrapeptide, or pentapeptide chosen, respectively, from the goups consisting of:n a) arginine, aspartic acid, lysine, leucine ; b) glycylaspartate, glycylglycine, aspartylarginine, leucylarginine, alanylglycine ; c) arginyllysylaspartate, aspartyllysylarginine, lysylprolylarginine, prolylprolylarginine, lysylhis- tidylglycinamide, prolylphenylalanylarginine, phenylalanylprolylarginine ; d) arginyllysylaspartylvaline, valylaspartyllysylarginine, threonylvalylleucylhistidine ; e) arginyllysylaspartylvalyltyrosine. |