| abstract |
Muscarinic receptor antagonist of formula (I), or its pharmaceutically acceptable salt, in which Y is a direct bond, -CH2-, - (CH2) 2-, -CH2O- or -CH2S-; and R1 is a group which corresponds to the formulas (a), (b), (c) or Het, in which R2 and R3 are, independently of one another, H, C1-C4 alkyl, alkoxy in C1-C4, - (CH2) nOH, halo, trifluoromethyl, cyano, - (CH2) nNR4R5, -CO (C1-C4 alkyl), -OCO (C1-C4 alkyl), -CH (OH) (C1-C4 alkyl ), -C (OH) (C1-C4 alkyl), -C (OH) (C1-C4 alkyl) 2, -SO2NH2, - (CH2) nCONR4R5 or - (CH2) nCOO (C1-C4 alkyl); R4 and R5 are, independently of one another, H or C1-C4 alkyl; n is 0, 1 or 2; X and X1 are, independently of one another, O or CH2; m is 1, 2 or 3; "Het" is pyridyl, pyrazinyl or thienyl. These compounds are useful in particular in the treatment of irritable bowel syndrome. |