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filingDate 1992-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1993-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0505210-A3
titleOfInvention Assay for measuring the degradation of type i collagen
abstract An antibody raised to type I collagen carboxyterminal cross-linked telopeptide isolated from decalcified human or animal bone, may be used in an assay to determine the concentration of liberated carboxyterminal telopeptide region of the type I collagen molecule in a sample. When the sample is a body fluid such as serum or urine the degradation product measured is resistant to further degradation, since it contains a multivalent intermolecular cross-link, and can thus be found in the body fluid. The assay may be used to assess the degradation of type I collagen, the major organic constituent of bone matrix.
priorityDate 1991-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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