http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0504751-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53d4d5676ced1e6a57a172c6ec661b8c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1133 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-5412 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 |
| filingDate | 1992-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c98dbe606b652ea831580298aae0367e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f577094ad933da45368ea2edb7f370a8 |
| publicationDate | 2000-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0504751-B1 |
| titleOfInvention | Method for the preparation of interleukin 6 |
| abstract | A process for the preparation of interleukin 6 from transformed bacterial strains which comprises: a) the culture of a bacterial host transformed with an exspression vector coding for interleukin-6; b) bacterial lysis, isolation by centrifugation of inclusion bodies containing interleukin-6 and their denaturation with guanidine hydrochloride; c) dialysis of the denaturated proteins in the presence of a redox system, preferably reduced and oxidized glutathione; d) anion-exchange chromatography of the dialysate on DEAE-Sepharose, eluting with a pH adjusted saline water-glycerol solution gradient, selecting and collecting the fractions containing interleukin-6 at the desired purity. p |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3124040-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022256688-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013147153-A1 |
| priorityDate | 1991-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 511.