| abstract |
Methods for determining collagen degradation in vivo, comprising quantifying the concentration of a peptide in a biological fluid, the peptide being a C-terminated type II collagen telopeptide containing a hydroxylysyl pyridinoline reticle, or a telopeptide type III collagen containing a hydroxylysyl pyridinoline reticle. Suitable methods include immunometric assays, fluorometric assays, as well as electrochemical quantitation titrations. The structures of specific peptides having crosshairs as well as materials for quantifying these peptides in a biological fluid are described. |