| abstract |
Sustained release compositions comprising cores including a pharmacologically active ingredient and having a diameter not greater than 5 mm, which cores are coated with a mixture comprising a) as a film forming agent at least one poly (ethyl acrylate, methyl methacrylate, trimethylammonioethyl methacrylate chloride) and b) at least one anionic surfactant wherein the ratio of a) to b) is from 100:1 to 10:1 by weight. Examples of suitable active ingredients are idazoxan, mebeverine, paracetamol and betahistine, and the preferred film forming agents are Eudragit RS and Eudragit RL. |