http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0501206-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2c01e7f7e1390eeca2fa25d6c1b66c85 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-235 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-11 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-825 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-235 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 |
| filingDate | 1992-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42ffc9eeddb4d0ca42dda5e8238b92b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5583de3507f1e363244c00e6e40be3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d4ab242c53d9ee63c6df5ac1cdc1867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb3dbfe777a899c487f8180b07345606 |
| publicationDate | 1992-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0501206-A2 |
| titleOfInvention | Phenone compounds, process for their preparation and their pharmaceutical preparations |
| abstract | R 1 = CH 3 R 2 = H, Cl, Br, I, Methyl, Hydroxy, Methoxy, Propoxy, Isopropoxy oder Ethoxy; R 3 = H oder β-D-Glykosyl; R 4 = H, Cl, Br, I, Methyl, Hydroxy, Methoxy, Propoxy, Isopropoxy oder Ethoxy; R 5 = H oder Hydroxy, nsowie die pharmazeutisch annehmbaren Salze, Ether und Ester, mit Ausnahme der Verbindungen 4-hydroxyacetophenon, 4-Hydroxy-3-methoxy-acetophenon, 4-Glucopyranosyloxy-acetophenon, 4-Glucopyranosyloxy-3-methoxyacetophenon, 4-Galactopyranosyloxy-3-methoxy-acetophenon, 4-Glucopyranosyloxy-3,5-dimethoxyace- tophenon und Galactopyranosyloxy-3,5-dimethoxy-acetophenon.The compound relates to certain new phenone derivatives of the general formula (I) in which mean: R 1 = CH 3 R 2 = H, Cl, Br, I, methyl, hydroxy, methoxy, propoxy, isopropoxy or ethoxy; R 3 = H or β-D-glycosyl; R 4 = H, Cl, Br, I, methyl, hydroxy, methoxy, propoxy, isopropoxy or ethoxy; R 5 = H or hydroxy, as well as the pharmaceutically acceptable salts, ethers and esters, with the exception of the compounds 4-hydroxy acetophenone, 4-hydroxy-3-methoxy-acetophenone, 4-glucopyranosyloxy-acetophenone, 4-glucopyranosyloxy-3-methoxyacetophenone, 4-galactopyranosyloxy-3-methoxy-acetophenone, 4-glucopyranosyloxy-3,5-dimethoxyoxyphenyl 3,5-dimethoxy-acetophenone.n n n R 1 = H, OH, Alkoxy oder G 1-8 -Alkyl; R2 - H oder C 1 - 4 -Alkoxy; R 3 = OH oder eine β-D/α-L-Glykosylgruppe (Di- oder Triglykosyl), die gegebenenfalls durch niedermolekulare C 1 - 4 -aliphatische oder aromatische Säuren substituiert ist/sind, R 4 = H oder C 1 -3 -Alkyl oder C 1 - 4 -Alkoxy; R 5 = H, Cl, Br oder I, wobei R 5 , wenn es Halogen bedeutet, in ortho-Stellung zu einer OH-Gruppe steht, und die pharmazeutisch annehmbaren Salze, Ether und Ester zusammen mit pharmazeutisch annehmbaren Träger- und Verdünnungsmitteln. The invention further relates to pharmaceutical preparations containing at least one compound of the general formula (II) in which mean: R 1 = H, OH, alkoxy or G 1-8 alkyl; R2 - H or C 1 - 4 alkoxy; R 3 = OH or a β-D / L-α-glycosyl (di- or Triglykosyl), optionally substituted by low molecular weight C 1 - 4 is substituted aliphatic or aromatic acids / are R 4 = H or C 1 -3 alkyl or C 1 - 4 alkoxy; R 5 = H, Cl, Br or I, where R 5 , when it is halogen, is ortho to an OH group, and the pharmaceutically acceptable salts, ethers and esters together with pharmaceutically acceptable carriers and diluents. n n n The new compounds, including the already known compounds, have an anti-inflammatory effect. In vivo, they particularly inhibit allergen and PAF-induced bronchial asthma. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109336935-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9522323-A1 |
| priorityDate | 1991-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 112.