http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0500171-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08 |
| filingDate | 1992-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2575af644fd629c28556304f585c0be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb1916e9a5068fb24f47d77f0bae7e49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3802dec65ca681d8e781e4b7417a1e0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_459d943865fae5cdf0ad4f4b707c58e2 |
| publicationDate | 1992-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0500171-A2 |
| titleOfInvention | Improved process for the preparation of chiral 4-aryloxyazetidinones |
| abstract | A process for preparing a single enantiomer of a 4-aryloxyazetidin-2-one derivative in optically pure form comprises reacting a hindered vinyl ester with chlorosulphonyl isocyanate; displacing the hindered acyloxy group with a phenolic derivative containing a protected carboxy group; deprotecting the carboxylate moiety; resolving with a chiral amine; filtering; and regenerating the desired enantiomer by acidification. A method for enriching the product obtained from the acyloxy displacement step in favour of the desired enantiomeric form, by treating with an asymmetric catalyst such as a chiral alkaloid derivative, is provided; as also is a method for racemising the unwanted antipode of the desired 4-aryloxyazetidin-2-one enantiomer. The invention further provides novel enantiomers based on the 4-aryloxyazetidin-2-one ring structure. |
| priorityDate | 1991-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.