| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03627f82d4edc6567f9627df6efdde5d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-301 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-00 |
| filingDate |
1992-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_505035668feb188fa82d416ffaf032ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f5bf50d82a3d66363312de4ed2e19cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b96caeb8e0f35af509505513e9da0ee6 |
| publicationDate |
1992-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0499376-A1 |
| titleOfInvention |
Precipitation-induced asymmetric transformation of chiral alpha-amino acids and salts thereof |
| abstract |
The present invention provides a method for resolving a mixture of optically active isomers of an α-amino acid to obtain the preferred optically active isomer. The mixture of isomers is contacted with at least one chiral resolving agent in an organic acid, which is at least a partial solvent for the α-amino acid, and in the presence of a mineral acid, which is present in a quantity which does not protonate the NH₂ functionality of the α-amino acid to an extent that diastereomer interconversion is substantially prevented, and in the presence of a catalytic amount of an aromatic aldehyde. The contacting results in simultaneous resolution of a desired diastereomer and interconversion of the remaining undesired diastereomer, to provide a very high yield of the desired diastereomer having a very high optical purity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009127446-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3348543-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9523805-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5767309-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102757356-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5869668-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1053669-C |
| priorityDate |
1991-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |