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filingDate 1992-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2000-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2000-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0498706-B2
titleOfInvention Process for the preparation of (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)methylpropionate
abstract In a starting mixture containing the dextrorotatory and levorotatory enantiomers of methyl trans-2,3-epoxy-3-(4-methoxyphenyl)propionate, the dextrorotatory enantiomer is subjected to transesterification in an anhydrous medium, which converts it to an insoluble derivative, in the presence of an enzyme which does not affect the levorotatory enantiomer. The latter is a synthetic intermediate of compounds such as Diltiazem.
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