http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0496373-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec5b8c0fc1f827c1360a8f5ea5652225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d669af06cb2abbcd6823699582a97002 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-12 |
| filingDate | 1992-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1cb08b2dd9dedc2c574d5fa887688b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_858920a870dc74f46e904403e5574f04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70ea0b49f32b3e795acc4464abfd99c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3db24a9cb873dac13b80585396ef41c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf323b9fee9e8a6be252132a561c7841 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f789d152d3e67cff67483dd5cc2f7e84 |
| publicationDate | 1992-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0496373-A1 |
| titleOfInvention | Process for preparing enzymatically protected and unprotected amino acids, di- and oligopeptides in aqueous solution |
| abstract | Protected and unprotected di- or oligopeptides are reacted by reacting an N-terminally protected amino acid or peptide alkyl ester of the formula XE-R¹ with an amino acid or a di- or oligopeptide or such a derivative of the general formula H₂N-Q-R² in aqueous solution Synthesized presence of a hydrolase and the reaction product separated from the reaction mixture is optionally freed from protective groups, where E is the residue of an amino acid or a di- or oligopeptide, R¹ is lower alkyl and X is a charge-carrying or at the pH values used for the reaction polar group which increases the solubility to compounds with X = H by a factor> 5, Q represents the remainder of an amino acid or a di- or oligopeptide and R² denotes an optionally esterified or amidated acid group. Preferably, a peptide or α-amino acid ester concentration of> 50 mM, in particular 100-1000 mM, and approximately comparable nucleophile and electrophile concentrations, as well as substrate / enzyme ratios of> 10⁵ (M / M) or> 10³ (M / M; with papain). The radicals X of the electrophile component are phthalyl, maleyl or citraconyl radicals and their derivatives or N-betainyl compounds. Instead of X or additionally, R 1 can also be a group which increases water solubility. Conveniently, R² can also increase solubility in the nucleophile. |
| priorityDate | 1991-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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