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filingDate 1992-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1992-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0495639-A1
titleOfInvention Use of interleukin-10 in adoptive immunotherapy of cancer
abstract A method is provided for using interleukin-10 in adoptive immunotherapy of cancer. A population of tumor-infiltrating lymphocytes (TILs) are expanded in culture in the presence of interleukin-2 (IL-2) and interleukin-10 (IL-10). After administration of the TILs to a patient, effective amounts of both IL-2 and IL-10 are administered to enhance the tumor-cell cytoxicity of the TILs and to reduce side-effects caused by IL-2-induced cytokine production in the TILs and other cells of the patient.
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