| abstract |
New substituted urea compounds whose formula is (I), or a pharmaceutically acceptable salt thereof, where R1 is a group whose formula is (II), (III), or (IV), where n is 2 or 3, p is 1 or 2, q is between 1 and 3, r is between 1 and 3 and R4 and R5 are H, C1-7 alkyl or C3-6 cycloalkyl; and R2 comprises an oxadiazole, substituted by C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-7 cycloalkyl, benzyl, phenyl, C1-6 alkoxy, C1-6 alkylthio, amino or alkylamino; or R2 is -C-R6 = N-O-R7 where R6 is hydrogen or methyl and R7 is C1-6 alkyl which may be substituted by C3-7 cycloalkyl; and where R3 is hydrogen, halogen, nitro, substituted amine, trifluoromethyl, C1-6 alkyl, or C1-6 alkoxy. The compounds are useful in pharmaceutical preparations which are used to treat mental disorders, nausea and vomiting. |