| abstract |
Compounds of which the formula is (I), where R1 is selected from the group consisting of an alkyl group, an aralkyl group, an alkenyl group, a cycloalkyl group, in which the alkyl, aralkyl, alkenyl group or cycloalkyl is substituted or unsubstituted with one or more substituents selected from the group consisting of a halogen atom, for example Cl or Br, a hydroxyl group or a straight or branched chain alkoxy group containing between 1 and 6 carbon atoms; and their pharmaceutically acceptable acid addition salts. These compounds are drug precursors of TRH and are characterized in that they have a higher lipophilicity than that of TRH and that they possess a high resistance to degradation by the enzymes inactivating TRH. Such compounds convert to TRH after administration. |