| abstract |
The present invention relates to novel 1,2,3,6-tetrahydropyridine derivatives of the general formula (I)n - wherein nR stands for hydrogen or an alkyl group, nX stands for an unsubstituted phenyl or benzyl group or for a phenyl or benzyl group substituted with a halogen atom, nY stands for hydrogen or halogen or a trifluoro-methyl group - nas well as enantiomers acid addition salts thereof. n The invention further extends to pharmaceutical compositions containing said compounds as active ingredient mainly for improving cerebral blood circulation and antihypoxic activity. The 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) are prepared by treating an oxo derivative of the general formula (II)n wherein R, X and Y are as given above in an organic solvent by a reducing agent and reacting the obtained 1,2,3,6-tetrahydropyridine derivative of the general formula (I), wherein R, X and Y are as given above, with a mineral or organic acid and converting the same, if desired, to an acid addition salt. |