| abstract |
Disclosed herein are a novel 2-substituted adenosine derivative having the following formula [I] <CHEM> wherein R represents a hydrogen atom or a hydroxyl group, m is an integer of 2 to 7, n is 0 or an integer of 1 to 3, and R<1>, R<2> and R<3>, which may be the same or different, each independently represent a hydrogen atom, a hydroxy protective group or a phosphoric acid residue, and salts thereof. The above compounds are excellent in a circulation ameliorating effect such as a vasodepressor activity, and have high selectivity for A2 receptors, but cause less undesirable side effects such as a suppressive effect on the heart. They are therefore effective when used in pharmaceutical compositions for circulatory diseases. |