http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0487636-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3082bdc3c9967d59703f4fd64438cdd8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 1990-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d0dca53b30a62e63e5cc219a342f16a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cda4f2b46e23d5b6eb1680b4af50b49 |
| publicationDate | 1992-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0487636-A1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF AN OIL EMULSION IN THE WATER OF A MEDICAMENT. |
| abstract | A method of preparing an oil-in-water emulsion of a sparingly water-soluble drug, comprising dissolving the drug (e.g. amphotericin B) in a solution at high or low pH before the formation of the drug emulsion. The high pH solution is preferably a 0.5 M solution of sodium hydroxide and / or potassium hydroxide, and the low pH solution is preferably a 0.5 M solution of hydrochloric acid. The method comprises the steps of (a) dissolving the medicament in a solution of high or low pH, (b) adding the solution thus obtained to a preformed emulsion, (c) adding to the emulsion an amount of a acid, an appropriate base or buffer making it possible to neutralize at least the product of stage (b), and (d) when an acid or a base is added in stage (c), optionally adding a sufficient buffer allowing the pH of the product of step (c) to be adjusted to the desired value. A drug emulsion produced by the method was also produced, in which the drug was first associated with the oil droplets. |
| priorityDate | 1989-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 122.