| abstract |
Compounds of formula (IVa)n wherein:n R 19 is -CH 2 CH 2 -, -CH 2 0-, -OCH 2 -, -NHCH 2 -, or -CH 2 NH-; Y is hydrogen or halogen attached at the 1, 2, 3 or 4 position; Y' is hydrogen or halogen attached at the 7, 8, 9 or 10 position; n is 0 to 3; each of p and q is 1 to 4; and R 20 and R 21 independently are hydrogen, or C 1 - 4 alkyl, or together with the nitrogen atom form a nitrogen-containing heterocyclic ring having four to six ring members, with the provisos thatn a) when R 19 is -CH 2 CH 2 -, -CH 2 0- or -OCH 2 -, p and q are each 1 and one of Y and Y' is halogen, the other is not hydrogen; and b) when R 19 is -CH 2 CH 2 - or -CH 2 0-, p and q are both 1 and each of Y and Y' is hydrogen or halogen, then n is not 2; or pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical formulations containing them. |