| abstract |
5-HT receptor antagonist compounds of Formula In in which:n the dashed line denotes an optional bond; X and Y are independently selected from hydrogen, halogen, hydroxy, lower alkoxy, benzyloxy, lower alkyl, nitro, amino, aminocarbonyl, (lower alkyl)amino, di(lower alkyl)amino, and (lower alkanoyl)amino; Z is -O-, -S- or - N ( R 2 )-; R 1 and R 2 are independently selected from hydrogen and lower alkyl or are together -(CH 2 ) n - wherein n is an integer from 2 to 4; and R 3 is selected fromn n n n in which: p is 0 or 1; q is 1, 2 or 3; and R 4 is C 1 - 7 alkyl; their pharmaceutically acceptable salts, individual isomers or mixtures of isomers, processes for their preparation, compositions containing them, and their use. |