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filingDate 1990-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1996-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3112fc4e27f5874cb08f307b0dc88c3
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publicationDate 1996-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0483194-B1
titleOfInvention IgG3 ANTIBODIES WITH SHORTENED HINGE REGION AND A COMPLEMENT ACTIVATION TEST
abstract PCT No. PCT/EP90/01172 Sec. 371 Date Mar. 12, 1992 Sec. 102(e) Date Mar. 12, 1992 PCT Filed Jul. 17, 1990 PCT Pub. No. WO91/01335 PCT Pub. Date Feb. 7, 1991.The present invention provides modified IgG3 containing human constant regions which has a shorter total-hinge region compared with normal human IgG3. Also described is a method for assaying an antibody against a specific antigen or hapten for its effectiveness in complement activation in an animal species, wherein the antibody is contacted with the immobilized antigen or hapten to form an immobilized antibody/antigen or hapten complex which is then contacted with complement from the relevant animal species, followed by assay of components of the complement complex thereby formed; whereby the extent and nature of complement activation by the antibody in the sample may be determined.
priorityDate 1989-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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