http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0480986-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80543d0a7ce91a89b82fd589016b9b65 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-23 |
| filingDate | 1990-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50543bee59879975c816027698738052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_202763cd88ffd307337e7a92390e18c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4d39d90a300549465caa42972eeb919 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dce2c69680292f095b9126c71adad232 |
| publicationDate | 1992-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0480986-A1 |
| titleOfInvention | 6-(hydronaphtyl-1-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-ones and the corresponding hydroxy acids |
| abstract | Compounds of either of the general formulas (I) and (II), in which: R1 represents a phenyl group C1-8 alkyl, C3-8 cycloakyle, C3-8 cycloalkyle (C1-8) alkyl, C2-8 alkenyl, or C1-6 substituted phenyl alkyl; R2 represents a C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl group or a C1-5 alkyl, C2-5 alkenyl, or C2-5 alkynyl group substituted by a substituted phenyl group; R3 represents a hydrogen atom or a substituent R4 or M; R4 represents a C1-5 alkyl group, or a C1-5 alkyl group substituted by a group selected from substituted phenyl, dimethylamino and acetylamino; R5 represents a hydrogen atom or a methyl or ethyl group, provided that R5 is not methyl when R2 is methyl; M represents a cation capable of forming a pharmaceutically acceptable salt; Q represents C = O or CHOH; and each of the bonds a, b, c, and d, is independently a single or double bond, unless a and c are double bonds, in which case b is a single bond; These compounds are inhibitors of 3-hydroxy-3 methylglutaryl-coenzyme A reductase (HMG-CoA Reductase), the enzyme limiting the rate of cholesterol biosynthesis in mammals, including humans, and are therefore useful in treatment of hypercholesterolemia in general and arteriosclerosis, hypercholesterolemia and familial hyperlipidemia in particular. |
| priorityDate | 1989-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 425.