http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0479971-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_634715a790f7ef0163a61e9f364bebcd |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1289 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-35 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-35 |
| filingDate | 1991-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75b7777364ea441d68bf44a5026dec9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d2b3ca47c6c69058dfdc78ff7ac87dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dab5b09a4e38cdcbe5666f0e59e0ee2 |
| publicationDate | 1992-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0479971-A1 |
| titleOfInvention | New proteins, peptides and corresponding dna or rna sequences and probes useful for diagnosing tuberculosis |
| abstract | The immunochemical properties of a 17 kDa protein antigen, fractionated, purified and sequenced for amino acids of Mycobacterium tuberculosis (South Indian isolate, SII 1), which is the cause of tuberculosis in humans, is described from 16 million patients worldwide. The 17 kDa protein antigen, which has an N-terminus of ATTLPVQR (aa 1-8) has at least three specific antibody binding epitopes located on linear peptides of the sequences RATYDKRYEVR (aa 91-101) and SEFAYGSFVR ( aa 68-77), which have been shown to be useful in a micro-ELISA for the early diagnosis of tuberculosis in humans by detection of specific antibodies. The 17kDa protein antigen, which was found to be mitogenic for peripheral blood lymphocytes, was found to carry three predicted T cell epitopes on linear peptides of the sequences SEFAYGSFVR (aa 68-77) and AELPGVDPDCDVCITR (aa 107-122 ). The 17 kDa antigen from M. tuberculosis (SII 1), which therefore possesses reaction properties to both B and T cells, was found to contain 131 amino acids and can be applied in immunodiagnosis , immunotherapy and immunoprophylaxis of tuberculosis in humans. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103063836-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111518165-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112125954-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111518165-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112125954-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103063836-A |
| priorityDate | 1990-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.