| abstract |
A novel physiologically active peptide originating in hog, represented by structural formula (I), and an acid addition salt thereof wherein terminals (1) and (2) are directly bonded to each other and so are terminals (3) and (4), and cystein residues (Cys) in the 6- and 22- positions form an intramolecular S - S bond with each other. Since it has both natriuretic and hypotensive activities, it is useful for treating cardiac edema, renal edema, hepatic edema, hypertension, congestive failure, and acute and chronic renal insufficiency. Since it has also activities of inhibiting the growth of vascular smooth muscle cells and producing cGMP, it is expected to be efficaceous against atherosclerosis. |