| abstract |
An instrument for handling liquids (11) comprises a work surface (22) with arrangements for modular locations supporting liquid containers, a pipette device with a pipette tip (33) coupled to a detection circuit, a robotic translation system (31) for moving the pipette tip, and a control system with a graphical user interface for programming and mounting. A calibration block (24) secured to the work surface allows calibration through a sensor tip, and cavities on the work surface provide modular locations. A washing location (25) for the pipette tip is provided on the work surface. An automated laboratory based on the liquid handling system includes a heater and cooler and a sealable incubation location (21), as well as a magnetic separation location (26 and 29). Methods of using the apparatus are described for transporting droplets of liquid, for aspirating with a minimal degree of tip contamination, for mixing liquids in containers, and for validating the work surface. A duckbill element (253) is intended to minimize evaporation and mutual contamination during processing, and is part of a container for storing and transporting liquids. |