| abstract |
According to an improved process for converting gentamicin B into isepamicin, 3,6'-di-N-formylgentamicin B is prepared, the 1-amine group is acylated with a protected N (S) -isoserine compound and all the blocking groups under conditions which allow high amounts of isepamicin to be obtained. The invention also relates to a new formylating agent, 2-formylmercaptobenzothiazole, and intermediate compounds. |