abstract |
Peptides of the formula <IMAGE> in which X is alkanoyl, A is optionally substituted D-Na(2), D-Phe or D-Trp, B is optionally substituted D-Phe, C is D-Pal(3) or optionally substituted D-Phe or D-Trp, and D is Tyr or His, E is D-Ser(R<1>), F is Leu, Trp or Phe, G is L-Ser(R<1>), H is Gly-NH2, D-Ala-NH2 or azagly-NH2 and R<1> is a glycosyl radical, have inhibitory effects on the formation of the gonadotropins lutropin and follitropin and thus also on the synthesis of testosterone and oestrogen. A process for the preparation of these peptides is described. |