| abstract |
Thiourea derivatives represented by the formula (I)n n wherein R₁ and R₂ are the same or different and each represents a lower alkyl group, or R₁ or R₂ taken together represent a group having the formula -(CH₂) m - in which m is 4 or 5, R₃ represents a lower alkyl group or a C₃-C₆ cycloalkyl group or a group having the formula -(CH₂) ℓ -R₄ in which R₄ is a phenyl, naphthyl, pyridyl, furyl or thienyl group optionally having 1-3 substituents selected from the group consisting of lower alkyl, lower alkoxy, phenoxy, lower alkylthio, hydroxy, halogen, nitro, cyano and trifluoromethyl, and ℓ represents an integer of 0 to 2 and n represents an integer of 1 to 5 or a physiologically acceptable salt thereof. n The compounds of the invention are useful as a therapeutic agent for peptic ulcers which is also effective on prevention of the recurrence after discontinuation of the administration due to the antimicrobial activity against Helicobacter pyroli . |