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filingDate 1990-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c37a0697eeebbfed57709b26c3ae9635
publicationDate 1992-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0465510-A1
titleOfInvention STABLE REFERENCE SOLUTION OF HEMOGLOBIN.
abstract We describe a stable reference solution to sample and control blood gas measurement methods. Said solution comprises an aqueous mixture, containing a hemoglobin solution derived from a mammalian source, which contains at least about 95% reduced hemoglobin. The solution further contains a bicarbonate buffer system, a metal catalyzed methemoglobin reduction system and an organic buffer. To obtain a control element having several properties similar to fresh and whole human blood, said reference solution is stored in a sealed ampoule, in an inert medium containing CO2, just before its use. The ampoule is then opened to balance said solution with a gaseous mixture having components which provide physiological gases to the solution. The solution is characterized after balancing by properties similar to that of fresh blood and has a long shelf life before balancing.
priorityDate 1989-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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