| abstract |
The present invention relates to derivatives of formula: <IMAGE> in which: R1 is a lower alkyl radical of 1 to 6 carbon atoms or a lower alkylene radical of 2 to 6 carbon atoms. R2 is a lower alkyl radical or an aromatic or a functional group or the hydrogen atom or a halogen atom. X can represent a bond, an oxygen or sulfur atom, an NH radical or a halogen. R3 or R'3 can be a functional group, a hydrogen atom, a lower alkyl radical, an aromatic ring or a heterocycle. R4 may represent a 2-sulfonic acid benzoyl amino group, 2-carboxy-3,6 dichloro benzoyl amino, 2-carboxyphenyl, 2-sulfoxyphenyl or (tetrazol-yl-5) -2 phenyl. As well as their addition salts and their use in therapeutics in particular for the treatment of cardiovascular diseases in particular for the treatment of hypertension and heart failure. |