abstract |
and pharmaceutically acceptable salts thereof possess activity as cell-selective HMG-CoA reductase inhibitors, thus making them useful as antihypercholesterolemic agents. In the above formula,n X is hydrogen or -S(O) m -R 1 and Y is hydrogen or S(O) n -R 2 , except that X and Y are not both hydrogen, or one of X and Y is -S-alkyl-SH and the other is hydrogen ; Z isn R is hydrogen, alkyl, cycloalkyl, aryl, or aralkyl ; R 1 and R 2 are each independently hydrogen, acyl, alkyl, alkenyl, alkynyl, aryl, aralkyl, alkaryl, cycloalkyl,n alkoxycarbonylalkylene, any of which is optionally substituted with 1, 2 or 3 hydroxy or halo groups (e.g., wherein R 1 and/or R 2 is trifluoromethyl) or R 1 and R 2 together are alkylene (i.e., forming a ring comprising the S(O) n and S(O) m groups and the carbon atom to which they are attached) of 1 to 6 carbon atoms ; R 3 is hydrogen, alkyl, ammonium, alkyl-ammonium, or alkali metal (such as Na, Li, or K) ; A 1 and A 2 are each independently hydrogen, alkyl, aryl, aralkyl, or alkaryl ; m is 0, 1, or 2 ; and n is 0, 1, or 2. |