http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0464112-B1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_63c2fe810ee39d72296e120300683f6e |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-90 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-167 |
filingDate | 1990-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 1994-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c391f499ee7ccdad3680074f260f4662 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd061f9c532a3c01dfd383e90d05faec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_337b79bf5e969f68eb6334040d21e714 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29d35becf43ae601cbedd0088aa49c16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_904b34a0a7abab71aa9ddddb28168b58 |
publicationDate | 1994-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-0464112-B1 |
titleOfInvention | A process for the preparation of 9-substituted guanine derivatives and intermediates for use in the process |
abstract | A process for the preparation of 9-substituted guanine derivatives of general formula (I), in which R is C1-C4-alkyl optionally substituted with one or more hydroxy groups, or R is (α), benzyl, ribosyl, 2'-deoxyribosyl or (CH2)n-OR1 where n is 1 or 2, and R1 is CH¿2?CH2OH or (β) or salts thereof, in which a 1-substituted 5-(thiocarbamoyl)amino-1H-imidazole-4-carboxamide of general formula (III), where R has the same meaning as in formula (I), is cyclized: a) by treatment with a heavy metal salt of the group of Cu-, Ag-, Pb- and Hg-salts in an aqueous alkaline medium containing at least four equivalents of OH?-¿ions at a temperature from about 0°C to the reflux temperature, or b) by treatment with a peroxy compound in an aqueous alkaline medium at a temperature of about 0-30°C, whereafter (I) is isolated by treatment with acid and, if desired, is converted into a salt. The invention further comprises intermediates for use in the preparation of the above-mentioned compounds. |
priorityDate | 1989-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 176.