http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0464112-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_63c2fe810ee39d72296e120300683f6e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-167 |
| filingDate | 1990-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c391f499ee7ccdad3680074f260f4662 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd061f9c532a3c01dfd383e90d05faec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29d35becf43ae601cbedd0088aa49c16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_904b34a0a7abab71aa9ddddb28168b58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_337b79bf5e969f68eb6334040d21e714 |
| publicationDate | 1992-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0464112-A1 |
| titleOfInvention | METHOD FOR PRODUCING 9-SUBSTITUTED GUANINE DERIVATIVES AND INTERMEDIATE PRODUCTS FOR USE IN THE METHOD. |
| abstract | The invention relates to a process for the preparation of guanine derivatives substituted in position 9, according to the general formula (I), in which R represents C1-C4 alkyl optionally replaced by one or more hydroxy groups, in which R represents (alpha), benzyl , ribosyl, 2'-deoxyribosyl or (CH2) n-OR1 where n represents 1 or 2, and R1 represents CH2CH2OH or (beta), or their salts, in which a 5- (thiocarbamoyl) amino-1H-imidazole-4- carboxamide substituted in position 1, of general formula (III), in which R is defined as in formula (I), is cyclized: a) by treatment using a heavy metal salt from the group consisting of salts of Cu, Ag, Pb and Hg in an aqueous alkaline medium containing at least four equivalents of OH- ions, at a temperature between approximately 0 ° C and the reflux temperature or b) by treatment with a compound peroxy in an aqueous alkaline medium at a temperature between about 0 and 30 ° C, after which (I) is isolated by treatment with acid, e t if desired, is transformed into a salt. The invention further comprises intermediates used in the preparation of the above-mentioned compounds. |
| priorityDate | 1989-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 184.