| abstract |
Disclosed herein are peptide derivatives of the formula R¹NH-CO-Q-C(O)-NR²-CH[CH₂C(O)-Y]-C(O)-NH-CH[CR³(R⁴)-COOH]-C(W)-NH-CHR⁵-Z wherein R¹ is an optionally substituted alkyl or optionally substituted phenylalkyl, R² is hydrogen or alkyl, R³ and R⁴ each independently is hydrogen or alkyl, or R³ and R⁴ are joined to form a cycloalkyl, R⁵ is alkyl, cycloalkyl or (cycloalkyl)alkyl, Q is a divalent radical, for example, -CH₂CH₂-, -CH=CH- or 1,2-cyclohexanediyl, which serves as a two carbon spacer, W is oxo or thioxo, Y is, for example, an alkoxy or a monosubstituted or disubstituted amino, and Z is a terminal unit, for example, hydrogen, COOH or CH₂OH. The derivatives are useful for treating herpes infections. |