| abstract |
Compounds of the formula:n or a pharmaceutically acceptable salt thereof,n wherein m is 0, 1 or 2 and n is 0 or 1; R 1 is hydrogen or lower alkyl; R 2 is C 1 -C 6 -alkyl substituted with a heterocyclic group or C 7 -C 16 -arylalkyl, wherein the aryl group is unsubstituted or substituted with from one to three non-hydrogen members independently selected from the group consisting of halogen, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, hydroxy, amino and C 1 -C 6 -alkylamino; R 3 , R 4 , R 5 and R 6 are independently selected from the group consisting of hydrogen, C 1 -C 6 -alkoxy, C 1 -C 6 -alkyl, halogen, and halo-C 1 -C 6 -alkyl, or any two of R 3 , R 4 , R 5 and R 6 taken together form a methylenedioxy group; and R 7 is hydrogen or C 1 -C 6 -alkyl. n These compounds are useful as inhibitors of the neuronal uptake of biogenic amines and for the treatment of affective disorders, such as, for example, depression. |