http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0460016-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6491 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577 |
| filingDate | 1990-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_daaef08e11a003dadea7e8588595cc64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d52c78f9918dc2b235a226278b99cc6b |
| publicationDate | 1991-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0460016-A1 |
| titleOfInvention | COLLAGENOLYTIC METALLOPROTEINASES ASSOCIATED WITH METASTASE. |
| abstract | The present invention relates to methods and compositions for diagnosing various types of cancer in humans, including metastatic breast cancer, carcinomatous colon astrocytoma, renal cell carcinoma and teratocarcinomatous malignant melanoma. The diagnostic method of the present invention consists in detecting a gelatinolytic and collagenolytic metalloproteinase type IV, the size of which has a molecular weight of approximately 88 to 92 kilodaltons. This high molecular weight type IV collagenolytic enzyme has been found to be associated with cancer, but has not been found in any non-cancer cells tested or in the serum of animals without tumors. This enzyme is associated with tumors in both rats and humans, the enzyme in each case being completely identical. Methods are described for isolating the enzyme from 88 to 92 kilodaltons, the enzyme thus isolated being useful as a regulatory enzyme and as a means of diagnostic testing. The isolated enzyme is further useful in the preparation of antibodies, including monoclonal antibodies, having specificity for the enzyme associated with metastasis. Techniques are also described for isolating and partially purifying the enzyme from both rats and humans. Methods are further described for performing both enzymatic and immunological type tests for the diagnosis of metastatic and recurrent diseases. |
| priorityDate | 1989-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.