| abstract |
The invention relates to compounds of formula (I) and salts thereofn n wherein R¹ and R² are the same or different and are each selected from hydroxy, or a group NR⁹R¹⁰ wherein R⁹ and R¹⁰ are each hydrogen, alkyl, aryl, arylalkyl or together with the nitrogen atom to which they are attached form a ring, optionally containing a further heteroatom and optionally further substituted by alkyl, aryl or arylalkyl; nR³ is selected from hydrogen, haloalkyl, alkyl and halo, R⁴ to R⁸ are the same or different, and are each selected from hydrogen, halo, nitro, amino, sulphonamido or alkylsulphonylamino; nor R⁴ and R⁵ or R⁵ and R⁶ may together form a carbocyclic ring; nwith the proviso that at least one of R⁴ to R⁸ is other than hydrogen. n The compounds may be used for the treatment or prophylaxis of a neurodegenerative or other neurological disorder of the CNS, the aetiology of which includes excessive release of the neurotransmitter glutamate. |