| abstract |
Compounds of the formulan n and pharmaceutically acceptable salts and tautomeric mixtures thereof possess activity as HMG-CoA reductase inhibitors, thus making them useful as antihypercholesterolemic agents. In the above formula, n Z isn n R¹ and R² are each independently fluoro or hydrogen, except that at least one of R¹ and R² is fluoro; n R³ is hydrogen, alkyl, cycloalkyl, aryl or arylalkyl; and n R⁴ is hydrogen, alkyl, ammonium, alkylammonium, or alkali metal. |