| abstract |
A novel pharmaceutical composition and method is disclosed for the treatment of cardiovascular diseases, e.g. myocardial ischemia and/or arrhythmia. The method and composition include an effective amount of a compound of the formulan n whereinn R and R₁ each independently represent hydrogen, halo, lower alkyl, lower alkoxy, trihalomethyl, nitro, amino or hydroxy; X represents oxa (-O-) or thia (-S-); B represents a basic nitrogen-containing radical of less than 12 carbon atoms; A and A' are independently selected from hydrogen or lower alkyl; m is zero or an integer from 1 to 3; n represents an integer from 2-5; p and p' are the same or different integer of 1 to 3; y is and R₂ is lower alkyl, aryl, aralkyl, cyclo-alkyl (lower alkyl), lower alkenyl, lower alkadienyl, α-substituted phenyl alkyl, aralkenyl, aralkynyl or heteroaryl. |