| abstract |
A 21-substituted steroid compound is disclosed. The compound has a structure of formula (I),n n wherein R¹ is a hydrogen atom, a lower alkyl, lower alkenyl, lower alkoxy, or phenyl group, R² is a hydroxyl group or an acyloxy group having 1-6 carbon atoms, R³ is a hydrogen atom or a lower alkyl group, or R² and R³ may together form a lower alkylidenedioxy group, X¹ and X² may be the same or different and individually represents a hydrogen atom or a halogen atom, Y¹ and Y² may be the same or different and individually represents a methylene group or a sulfur atom, Z is a sulfur atom or an imino group, the wave line means that the configuration of R³ may be of either α or β, and dotted line between the 1 and 2 position means that the bond may be the double bond. It has excellent anti-inflammatory, anti-allergic and anti-asthma activities with little side effects, and is useful for the prevention, cure, and treatment of on inflammation, allergic diseases, rheumatism, and the like. |