| abstract |
In accordance with the present invention, novel neutral endopeptidase inhibitors and methods for their use are disclosed. Compounds of the present invention, useful, for example, as cardio-vascular agents, have the general formula <CHEM> <CHEM> phenyl substituted with alkyl of 1 to 4 carbons, alkoxy of 1 to 4 carbons, alkylthio of 1 to 4 carbons, hydroxy, halo, nitro or trifluoromethyl, or a heterocyclic group selected from thiazolyl, 4,5-dihydrothiazolyl, pyridyl, oxazolyl, isoxazolyl, imidazolyl, tetrazolyl, benzimidazolyl, benzothiazolyl or benzoxazolyl including substituted heterocyclic groups wherein the substituents are selected from halo, alkyl and phenyl; <IMAGE> and wherein the various groups are as defined herein.p |