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publicationDate 1991-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0449111-A1
titleOfInvention Process for preparing 2-(3-aminopropyl)-cycloalkylamines
abstract a) die 2-(2-Cyanoethyl)-cycloalkanone der Formel II in einem ersten Reaktionsraum mit überschüssigem Ammoniak an aciden Heterogenkatalysatoren bei Temperaturen von 20 bis 150°C und Drücken von 15 bis 500 bar umsetzt und b) die entstandenen Reaktionsprodukte in einem zweiten Reaktionsraum mit Wasserstoff in Gegenwart von überschüssigem Ammoniak an cobalt-, nickel-, ruthenium- und/oder anderen edelmetallhaltigen Katalysatoren gegebenenfalls mit basischen Komponenten oder auf neutralen oder basischen Trägern bei Temperaturen von 60 bis 150°C und Drücken von 100 bis 500 bar hydriert sowie die neue Verbindung 2-(3-Aminopropyl)-cyclopentylamin. Process for the preparation of 2- (3-aminopropyl) -cycloalkylamines of the general formula I. in which the index n is an integer from 1 to 4, from 2- (2-cyanoethyl) cycloalkanones of the general formula II in which the index n has the meaning given above, by operating in two spatially separated reaction spaces a) the 2- (2-cyanoethyl) cycloalkanones of the formula II in a first reaction space with excess ammonia over acidic heterogeneous catalysts at temperatures of 20 to 150 ° C and pressures of 15 to 500 bar and b) the reaction products formed in a second reaction space with hydrogen in the presence of excess ammonia over cobalt, nickel, ruthenium and / or other noble metal-containing catalysts, optionally with basic components or on neutral or basic supports at temperatures of 60 to 150 ° C and Pressures from 100 to 500 bar hydrogenated and the new compound 2- (3-aminopropyl) -cyclopentylamine.
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